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Methamphetamine powder is a powerful, highly addictive stimulant that affects the central nervous system. Also known as meth, chalk, ice, and crystal, among many other terms, it takes the form of a white, odorless, bitter-tasting crystalline powder that easily dissolves in water or alcohol.

Description

Formula: C10H15N
IUPAC ID: N-methyl-1-phenylpropan-2-amine
Other names: N-methylamphetamine, N,α-dimethylphenethylamine, desoxyephedrine
Duration of action: 10–20 hours
Onset of action: Rapid

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Methamphetamine powder is a powerful, highly addictive stimulant that affects the central nervous system. Also known as meth, chalk, ice, and crystal, among many other terms, it takes the form of a white, odorless, bitter-tasting crystalline powder that easily dissolves in water or alcohol.

Methamphetamine powder was developed early in the 20th century from its parent drug, amphetamine, and was used originally in nasal decongestants and bronchial inhalers. Like amphetamine, methamphetamine causes increased activity and talkativeness, decreased appetite, and a pleasurable sense of well-being or euphoria. However, methamphetamine differs from amphetamine in that, at comparable doses, much greater amounts of the drug get into the brain, making it a more potent stimulant. It also has a longer-lasting and more harmful effects on the central nervous system. These characteristics make it a drug with high potential for widespread abuse.

Meth (Methamphetamine) powder and Crystal Meth has been classified by the U.S. Drug Enforcement Administration as a Schedule II stimulant, which makes it legally available only through a nonrefillable prescription. Medically it may be indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and as a short-term component of weight-loss treatments, but these uses are limited and it is rarely prescribed; also, the prescribed doses are far lower than those typically abused.

Methamphetamine comes in many forms and can be smoked, snorted, orally ingested, or injected. The drug alters moods in different ways, depending on how it is taken. Immediately after smoking the drug or injecting it intravenously, the user experiences an intense rush or “swap” that lasts only a few minutes and is described as extremely pleasurable. Snorting or oral ingestion produces euphoria — a high but not an intense rush. Snorting produces effects within 3 to 5 minutes, and oral ingestion produces effects within 15 to 20 minutes.

As with similar stimulants, methamphetamine most often is used in a “binge and crash” pattern. Because tolerance for methamphetamine occurs within minutes — meaning that the pleasurable effects disappear even before the drug concentration in the blood falls significantly — users try to maintain the high by binging on the drug.

In the 1980’s, “ice,” a smokable form of methamphetamine, came into use. Ice is a large, usually clear crystal of high purity that is smoked in a glass pipe like crack cocaine. The smoke is odorless, leaves a residue that can be resmoked, and produces effects that may continue for 12 hours or more.

The Brain – Dopamine plays an important role in the regulation of pleasure. In addition to other regions, dopamine is manufactured in nerve cells within the ventral tegmental area and is released in the nucleus accumbens and the frontal cortex.

 

Methamphetamine, commonly known as meth, is a potent and highly addictive stimulant that affects the central nervous system. It is a dangerous and illegal drug that can have severe physical and psychological consequences for those who use it. One of the concerning aspects of meth use is its potential to cause or exacerbate mental health issues. This article explores the relationship between methamphetamine use and mental illness, including the potential risks, underlying mechanisms, and the importance of seeking treatment for both addiction and mental health conditions.

Understanding Methamphetamine Use

Methamphetamine is a synthetic drug that comes in the form of a white, odorless, crystalline powder or in crystal chunks commonly known as “crystal meth.” It can be ingested orally, snorted, smoked, or injected. When consumed, methamphetamine increases the release of dopamine, a neurotransmitter associated with pleasure and reward, leading to intense feelings of euphoria and increased energy.

However, methamphetamine use is associated with serious health risks and negative consequences. The drug’s effects on the brain’s reward system can lead to compulsive drug-seeking behavior and addiction. Additionally, long-term use of methamphetamine can have detrimental effects on physical health, including cardiovascular issues, severe dental problems (often referred to as “meth mouth”), and weight loss.

The Link Between Meth Use and Mental Illness

Psychiatric Symptoms during Intoxication: While under the influence of meth, users may experience a wide range of psychiatric symptoms, including:
Agitation and Irritability: Meth use can lead to irritability and aggressive behavior.
Anxiety: Users may experience intense feelings of anxiety and paranoia, sometimes leading to hallucinations or delusions.
Mood Swings: Methamphetamine can cause drastic changes in mood, including periods of extreme happiness followed by deep depression.
Cognitive Impairment: Users may have difficulty thinking clearly and making rational decisions.
Psychosis: In some cases, meth use can lead to a state of acute psychosis, characterized by severe hallucinations and delusions.
Long-term Psychiatric Effects: Chronic methamphetamine use can have more lasting effects on mental health. Some potential long-term psychiatric effects of meth use include:
Depression: Prolonged meth use can lead to a significant decrease in dopamine levels, resulting in feelings of depression and anhedonia (inability to experience pleasure).
Anxiety Disorders: Methamphetamine use can trigger or exacerbate anxiety disorders, leading to chronic anxiety and panic attacks.
Cognitive Impairment: Chronic meth use has been associated with cognitive deficits, including problems with memory, attention, and decision-making.
Paranoia and Psychosis: Long-term meth use can lead to chronic paranoia and psychosis, even in the absence of active drug use.
Co-occurring Substance Use and Mental Health Disorders: Methamphetamine users are at an increased risk of developing co-occurring substance use and mental health disorders. They may turn to meth as a way to self-medicate underlying mental health issues or to cope with emotional pain.
Neurotoxicity and Brain Damage: Methamphetamine is neurotoxic and can cause damage to brain cells and neurotransmitter systems. The long-term effects of this neurotoxicity can contribute to the development of mental health issues.
Underlying Mechanisms

The exact mechanisms by which methamphetamine use contributes to mental illness are not fully understood. However, several factors are believed to play a role:

Dopamine Dysregulation: Methamphetamine causes a rapid release of dopamine, flooding the brain’s reward system with excessive amounts of this neurotransmitter. Over time, this can lead to a depletion of dopamine receptors and a decrease in dopamine levels. This dysregulation of the dopamine system is associated with various mental health issues, including depression and anhedonia.
Neuroinflammation: Methamphetamine use can trigger neuroinflammation, which involves the activation of the brain’s immune response. Chronic neuroinflammation can damage brain cells and lead to cognitive deficits and mood disturbances.
Changes in Brain Structure: Long-term methamphetamine use has been associated with structural changes in the brain, particularly in areas responsible for decision-making, memory, and emotions. These changes may contribute to cognitive impairment and mood disorders.
Stress Response: Methamphetamine use activates the body’s stress response system, leading to increased levels of stress hormones like cortisol. Chronic activation of the stress response can have adverse effects on mental health.
Treatment and Recovery

Treating methamphetamine addiction and co-occurring mental health issues requires a comprehensive and integrated approach. It is essential to address both the addiction and the underlying mental health concerns simultaneously to achieve lasting recovery. Here are some key components of effective treatment:

Detoxification: Individuals with a methamphetamine addiction may need to undergo supervised detoxification to safely manage withdrawal symptoms. Detox should be followed by comprehensive treatment for addiction and mental health.
Behavioral Therapy: Behavioral therapies, such as Cognitive-Behavioral Therapy (CBT) and Contingency Management, have shown promise in treating methamphetamine addiction and co-occurring mental health issues. These therapies help individuals identify and modify destructive thought patterns and behaviors associated with drug use.
Medication-Assisted Treatment (MAT): There are currently no FDA-approved medications specifically for the treatment of methamphetamine addiction. However, research is ongoing, and some medications may be used off-label to manage certain symptoms of withdrawal and reduce drug cravings.
Dual Diagnosis Treatment: Dual diagnosis treatment focuses on addressing both substance use and mental health issues simultaneously. Integrated treatment plans consider the interconnected nature of these conditions and provide specialized care to promote recovery in all areas of life.
Supportive Services: Supportive services, such as counseling, peer support groups, and vocational assistance, can be valuable in helping individuals navigate the challenges of recovery and rebuild their lives.
Relapse Prevention: Relapse prevention strategies are essential in reducing the risk of returning to drug use after treatment. These strategies may include coping skills training, identifying triggers, and developing a relapse prevention plan.
Methamphetamine use is associated with a range of psychiatric symptoms during intoxication and can have lasting effects on mental health, even after the drug has left the system. The drug’s impact on the brain’s reward system, neurotoxicity, and changes in brain structure contribute to the development of mental health issues, including depression, anxiety, paranoia, and cognitive impairments.

Effective treatment for methamphetamine addiction and co-occurring mental health issues requires an integrated and comprehensive approach that addresses both the addiction and underlying mental health concerns. Seeking professional help and support is crucial for individuals struggling with methamphetamine use and mental illness. Recovery is possible, and with the right resources and treatment, individuals can achieve lasting sobriety and improved mental well-being.

 

4-Aco-DMT

4-Aco-dmt is a synthetically produced psychoactive drug and has been suggested to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.

 

Also psilacetin, 4-acetoxy-DMT, or 4-AcO-DMT,O-Acetylpsilocin). It is a synthetically produced psychoactive drug. It is the acetylated form of the psilocybin mushroom. Alkaloid psilocin and is a lower homolog of 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT.

.4-Aco-dmt is a synthetically produced psychoactive drug and has been suggested to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.

Also psilacetin, 4-acetoxy-DMT, or 4-AcO-DMT,O-Acetylpsilocin). It is a synthetically produced psychoactive drug. It is the acetylated form of the psilocybin mushroom. Alkaloid psilocin and is a lower homolog of 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT. Buy 4-Aco-DMT online.

1 Product name 4-Aco-DMT
2 Full chemical names 3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl acetate
3 Formal Name psilacetin, 4-acetoxy-DMT,O-Acetylpsilocin
4 CAS num 92292-84-7
5 Molecular Formulas C14H18N2O2
6 Average mass 246.3049 g·mol−1
7 Purity ≥99.0%
8 Stability 2 years
9 Storage -20 °C
10 Formulation A powder solid
11 λmax 221, 315 nm
12 Shipping Wet ice in continental US; may vary elsewhere ,
It is the acetylated form of the psilocybin mushroom alkaloid psilocin. 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT.
The compound has been suggested by David Nichols to be a potentially useful alternative to psilocybin. For pharmacological studies, as they are both believed to be prodrugs of psilocin.
Its structural similarities to psilocin and psilocybin results in an identical subjective effect profile. The three compounds can feel indistinguishable from each other.
This allows 4-AcO-DMT to function as a perfect substitute for psilocybin mushrooms.

4-Acetoxy-N,N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, and psilacetin) is a novel psychedelic substance of the tryptamine class. 4-AcO-DMT is chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). It belongs to a group known as the substituted tryptamines which act by stimulating serotoninreceptors in the brain. SHOP NOW!

Pharmacology

In the body O-acetylpsilocin is dictated to psilocin by deacetylase/acetyltransferase during first pass metabolism and during subsequent passes through the liver (clear as psilacetin is also active via parenteral routes of ingestion). Claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin differ: some users report that O-acetylpsilocin lasts slightly longer while others report it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by O-acetylpsilocin more closely resemble those produced by DMT than those produced by psilocin. These differences could be if psilocetin is active itself and not merely as a prodrug. Despite this, there have been no controlled clinical studies to distinguish any effects of psilocetin, psilocin, and psilocybin from one another.

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